Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective

@article{Bruno2000SelectiveBO,
  title={Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective},
  author={V. Bruno and I. Ksiazek and G. Battaglia and S. Lukic and T. Leonhardt and D. Sauer and F. Gasparini and R. Kuhn and F. Nicoletti and P. Flor},
  journal={Neuropharmacology},
  year={2000},
  volume={39},
  pages={2223-2230}
}
We have used potent and selective non-competitive antagonists of metabotropic glutamate receptor subtype 5 (mGlu5) -- 2-methyl-6-phenylethynylpyridine (MPEP), [6-methyl-2-(phenylazo)-3-pyridinol] (SIB-1757) and [(E)-2-methyl-6-(2-phenylethenyl)pyridine] (SIB-1893) - to examine whether endogenous activation of this particular metabotropic glutamate receptor subtype contributes to neuronal degeneration. In cortical cultures challenged with N-methyl-D-aspartate (NMDA), all three mGlu5 receptor… Expand
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  • V. Bruno, G. Battaglia, +6 authors F. Nicoletti
  • Biology, Medicine
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  • 2001
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