Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice.

@article{Storto2003SelectiveBO,
  title={Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice.},
  author={Marianna Storto and Richard Teke Ngomba and Giuseppe Battaglia and Isabel Freitas and Patrizia Griffini and Plinio Richelmi and Ferdinando Nicoletti and Mariapia Vairetti},
  journal={Journal of hepatology},
  year={2003},
  volume={38 2},
  pages={179-87}
}
BACKGROUND/AIMS mGlu5 metabotropic glutamate receptor antagonists protect rat hepatocytes against hypoxic death. Here, we have examined whether mGlu5 receptor antagonists are protective against liver damage induced by oxidative stress. METHODS Toxicity of isolated hepatocytes was induced by tert-butylhydroperoxide (t-BuOOH) after pretreatment with the… CONTINUE READING