Selective blockade of endothelial NF-kappaB pathway differentially affects systemic inflammation and multiple organ dysfunction and injury in septic mice.

@article{Xu2010SelectiveBO,
  title={Selective blockade of endothelial NF-kappaB pathway differentially affects systemic inflammation and multiple organ dysfunction and injury in septic mice.},
  author={Honglei Xu and Xiaobing Ye and Harry Steinberg and Shu Fang Liu},
  journal={The Journal of pathology},
  year={2010},
  volume={220 4},
  pages={490-8}
}
Endothelium has long been considered both a source and a target of systemic inflammation. However, to what extent endothelial activation contributes to systemic inflammation remains unclear. This study addresses the relative contribution of endothelial activation to systemic inflammation and multiple organ dysfunction and injury (MOD/I) in an E. coli… CONTINUE READING