Selective blockade of astrocytic glutamate transporter GLT-1 with dihydrokainate prevents neuronal death during ouabain treatment of astrocyte/neuron cocultures.

@article{Kawahara2002SelectiveBO,
  title={Selective blockade of astrocytic glutamate transporter GLT-1 with dihydrokainate prevents neuronal death during ouabain treatment of astrocyte/neuron cocultures.},
  author={Koichi Kawahara and Rui Hosoya and Hideomi Sato and Motoki Tanaka and Takayuki Nakajima and Sadahiro Iwabuchi},
  journal={Glia},
  year={2002},
  volume={40 3},
  pages={337-49}
}
Glutamate (Glu) is a major excitatory neurotransmitter of the mammalian central nervous system and under normal conditions plays an important role in information processing in the brain. Therefore, extracellular Glu is subject to strong homeostasis. Astrocytes in the brain have been considered to be mainly responsible for the clearance of extracellular Glu. In this study, using mixed neuron/astrocyte cultures, we investigated whether astrocytic Glu transporter GLT-1 is crucial to the survival… CONTINUE READING

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