Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead.

@article{Alkondon1990SelectiveBO,
  title={Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead.},
  author={Manickavasagon Alkondon and Andreia Cerqueira Costa and V B Radhakrishnan and Robert S. Aronstam and Edson X. Albuquerque},
  journal={FEBS letters},
  year={1990},
  volume={261 1},
  pages={124-30}
}
The effect of Pb2+ on glutamate receptor activity in rat hippocampal neurons was investigated with a view of explaining the cognitive and learning deficits produced by this heavy metal. Pb2+ (2.5-50 microM) selectively inhibited N-methyl-D-aspartate (NMDA)-induced whole-cell and single-channel currents in a concentration-dependent but voltage-independent manner, without significantly altering currents induced by either quisqualate or kainate. The frequency of NMDA-induced channel activation was… CONTINUE READING

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