Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils

@article{Salom2006SelectiveBO,
  title={Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils},
  author={N. Salom{\'e} and J. Stemmelin and C. Cohen and G. Griebel},
  journal={Pharmacology Biochemistry and Behavior},
  year={2006},
  volume={83},
  pages={533-539}
}
There is a growing interest in the potential anxiolytic- and antidepressant-like effects of compounds that target neurokinin receptors. Since the structure and the pharmacology of the human neurokinin receptor resembles that of gerbils, rather than that of mice or rats, we decided to investigate the anxiolytic- and /or antidepressant-like effects of NK1 (SSR240600), NK2 (saredutant) and NK3 (osanetant) receptor antagonists in gerbils. It was found that saredutant (3-10 mg/kg, p.o.) and… Expand
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