Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils

@article{Salom2006SelectiveBO,
  title={Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils},
  author={Nicolas Salom{\'e} and Jeanne Stemmelin and Caroline Cohen and G. E. Griebel},
  journal={Pharmacology Biochemistry and Behavior},
  year={2006},
  volume={83},
  pages={533-539}
}
There is a growing interest in the potential anxiolytic- and antidepressant-like effects of compounds that target neurokinin receptors. Since the structure and the pharmacology of the human neurokinin receptor resembles that of gerbils, rather than that of mice or rats, we decided to investigate the anxiolytic- and /or antidepressant-like effects of NK1 (SSR240600), NK2 (saredutant) and NK3 (osanetant) receptor antagonists in gerbils. It was found that saredutant (3-10 mg/kg, p.o.) and… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

Current investigational drugs for major depression.

  • Expert opinion on investigational drugs
  • 2009
VIEW 7 EXCERPTS
CITES RESULTS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 57 REFERENCES

Tonic immobility in gerbils: a new model for detecting antidepressant-like effects

J Simiand, J Guitard, G Griebel, P. Soubrie
  • Behav Pharmacol
  • 2003
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…