Selective blockade of N-type calcium channels by levetiracetam.

  title={Selective blockade of N-type calcium channels by levetiracetam.},
  author={Elena A Lukyanetz and Vyacheslav M. Shkryl and Platon Grigor’evich Kostyuk},
  volume={43 1},
PURPOSE We investigated the effect of the new antiepileptic drug (AED) levetiracetam (LEV) on different types of high-voltage-activated (HVA) Ca2+ channels in freshly isolated CA1 hippocampal neurons of rats. METHODS Patch-clamp recordings of HVA Ca2+ channel activity were obtained from isolated hippocampal CA1 neurons. LEV was applied by gravity flow from a pipette placed near the cell, and solution changes were made by electromicrovalves. Ca2+ channel blockers were used for separation of… CONTINUE READING

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