Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis.

@article{Haanstra2015SelectiveBO,
  title={Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis.},
  author={Krista G Haanstra and Karin Dijkman and Noun Bashir and Jan Niklas Bauer and C. Devi Shyamala Mary and Nicolas Poirier and Paul Baker and Claire Crossan and Linda Scobie and Bert A 't Hart and Bernard Vanhove},
  journal={Journal of immunology},
  year={2015},
  volume={194 4},
  pages={
          1454-66
        }
}
Costimulatory and coinhibitory receptor-ligand pairs on T cells and APC control the immune response. We have investigated whether selective blockade of CD28-CD80/86 costimulatory interactions, which preserves the coinhibitory CTLA4-CD80/86 interactions and the function of regulatory T (Treg) cells, abrogates the induction of experimental autoimmune encephalomyelitis (EAE) in rhesus monkeys. EAE was induced by intracutaneous immunization with recombinant human myelin oligodendrocyte glycoprotein… CONTINUE READING
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