Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents.

@article{Bonaventure2007SelectiveBO,
  title={Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents.},
  author={Pascal Bonaventure and Lisa Kelly and Leah E Aluisio and Jonathan A. Shelton and Brian Lord and Ruggero Galici and Kirsten L. Miller and John R Atack and Timothy W. Lovenberg and Christine Dugovic},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={321 2},
  pages={
          690-8
        }
}
  • Pascal Bonaventure, Lisa Kelly, +7 authors Christine Dugovic
  • Published in
    The Journal of pharmacology…
    2007
  • Medicine, Chemistry
  • Evidence has accumulated supporting a role for 5-hydroxytryptamine (5-HT)7 receptors in circadian rhythms, sleep, and mood disorders, presumably as a consequence of the modulation of 5-HT-mediated neuronal activity. We hypothesized that a selective 5-HT7 receptor antagonist, (2R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]-pyrrolidine (SB-269970), should increase activity of 5-HT neurons and potentiate the effect of selective serotonin reuptake inhibitors (citalopram). In… CONTINUE READING

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