Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha1A‐adrenoceptor subtype in the rat

  title={Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha1A‐adrenoceptor subtype in the rat},
  author={Miriam Alvarez-Guerra and Nadine Bertholom and Ricardo P. Garay},
  journal={Fundamental \& Clinical Pharmacology},
Abstract— The alpha1‐adrenergic blocking activity of nicergoline was re‐examined in rats, with a particular emphasis on alpha1‐adrenoceptor subtypes. In pithed rats, nicergoline and prazosin infused at a single small dose (0.5 μg/kg/min i.v.) produced a substantial and identical shift to the right of the control dose pressor response curve to the specific alpha1‐agonist cirazoline (ED50 = 4.0 ± 0.1, 4.0 ± 0.1 and 0.9 ± 0.01 μg/kg i.v. for nicergoline, prazosin and vehicle respectively). In the… 
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