Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver.

@article{Bennett2008SelectiveBO,
  title={Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver.},
  author={Mary K Bennett and Young-Kyo Seo and Shrimati Datta and Dong-Ju Shin and Timothy F. Osborne},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 23},
  pages={15628-37}
}
Mice were subjected to different dietary manipulations to selectively alter expression of hepatic sterol regulatory element-binding protein 1 (SREBP-1) or SREBP-2. mRNA levels for key target genes were measured and compared with the direct binding of SREBP-1 and -2 to the associated promoters using isoform specific antibodies in chromatin immunoprecipitation studies. A diet supplemented with Zetia (ezetimibe) and lovastatin increased and decreased nuclear SREBP-2 and SREBP-1, respectively… CONTINUE READING

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Regulation of SREBP Target Genes in Liver 15636 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • M S.
  • U niersity of Saatchew an on M arch 14,
  • 2008
1 Excerpt

BIOLOGICAL CHEMISTRY 15637 at U niersity of Saatchew an on M arch 14, 2015 hp://w w w .jb.org/ D

  • M. Casado, V. S. Vallet, A. Kahn, S. Vaulont
  • J. Biol
  • 1999
1 Excerpt

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