Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites.

@article{Marullo1990SelectiveBO,
  title={Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites.},
  author={Stefano Marullo and Laurent Jean Emorine and Arthur Donny Strosberg and Colette Delavier-Klutchko},
  journal={The EMBO journal},
  year={1990},
  volume={9 5},
  pages={1471-6}
}
The molecular basis of ligand binding selectivity to beta-adrenergic receptor subtypes was investigated by designing chimeric beta 1/beta 2-adrenergic receptors. These molecules consisted of a set of reciprocal constructions, obtained by the exchange between the wild-type receptor genes of one to three unmodified transmembrane regions, together with their extracellular flanking regions. Eight different chimeras were expressed in Escherichia coli and studied with selective beta-adrenergic… CONTINUE READING

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