Selective binding of bladder muscarinic receptors in relation to the pharmacokinetics of a novel antimuscarinic agent, imidafenacin, to treat overactive bladder.

@article{Yamada2011SelectiveBO,
  title={Selective binding of bladder muscarinic receptors in relation to the pharmacokinetics of a novel antimuscarinic agent, imidafenacin, to treat overactive bladder.},
  author={Shizuo Yamada and Masanao Seki and Masaki Ogoda and Ayako Fukata and Miho Nakamura and Yoshihiko Ito},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={336 2},
  pages={
          365-71
        }
}
The binding of orally administered imidafenacin, used to treat overactive bladders, to muscarinic receptors in rat tissue was characterized based on pharmacokinetics. The binding in six tissues including bladder tissue was measured using [N-methyl-(3)H] scopolamine methyl chloride ([(3)H]NMS). Pharmacokinetic parameters were estimated from measurements of the concentration of imidafenacin in serum, the bladder, and the submaxillary gland by liquid chromatography-mass spectrometry/mass… CONTINUE READING

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