Selective bilateral hippocampal volume loss in chronic schizophrenia

@article{Velakoulis2001SelectiveBH,
  title={Selective bilateral hippocampal volume loss in chronic schizophrenia},
  author={Dennis Velakoulis and Geoffrey W. Stuart and Stephen J. Wood and Deidre J. Smith and Warrick J. Brewer and Patricia M. Desmond and Bruce S. Singh and David Copolov and Christos Pantelis},
  journal={Biological Psychiatry},
  year={2001},
  volume={50},
  pages={531-539}
}
BACKGROUND The hippocampus is implicated in the pathophysiology of schizophrenia; however, volumetric changes are subtle and have limited diagnostic specificity. It is possible that the shape of the hippocampus may be more characteristic of schizophrenia. METHODS Forty-five patients with chronic schizophrenia and 139 healthy control subjects were scanned using magnetic resonance imaging. Hippocampi were traced manually, and two-dimensional shape information was analyzed. RESULTS Two shape… Expand
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