Selective autophagy: ubiquitin-mediated recognition and beyond

  title={Selective autophagy: ubiquitin-mediated recognition and beyond},
  author={Claudine Kraft and Matthias Peter and Kay Hofmann},
  journal={Nature Cell Biology},
Eukaryotic cells use autophagy and the ubiquitin–proteasome system as their major protein degradation pathways. Whereas the ubiquitin–proteasome system is involved in the rapid degradation of proteins, autophagy pathways can selectively remove protein aggregates and damaged or excess organelles. Proteasome-mediated degradation requires previous ubiquitylation of the cargo, which is then recognized by ubiquitin receptors directing it to 26S proteasomes. Although autophagy has long been viewed as… CONTINUE READING
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