Selective attenuation of acute lung ventilatory injury by methylene blue after liver ischemia-reperfusion: a drug response study in an isolated perfused double organ model.

@article{Weinbroum2001SelectiveAO,
  title={Selective attenuation of acute lung ventilatory injury by methylene blue after liver ischemia-reperfusion: a drug response study in an isolated perfused double organ model.},
  author={Avraham Weinbroum and Gideon Paret and Oded Szold and Valery Rudick and L Krupitzky},
  journal={Transplantation},
  year={2001},
  volume={72 3},
  pages={
          385-92
        }
}
BACKGROUND Liver transplantation-related ischemia-reperfusion (IR) is associated with the generation of stress oxidants that can spread damage remotely. Methylene blue (MB) had been shown to reduce lung neutrophils sequestration after in vivo intestinal IR and to have a dose-dependent potential for abrogating oxidant-induced ex vivo aortal ring reperfusion injury after liver IR. We now investigated MB's dose-dependent capabilities in preventing acute lung injury after the same liver IR… CONTINUE READING
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