Selective arrangement of ubiquitinated and D1 protein-containing nucleosomes within the Drosophila genome.

@article{Levinger1982SelectiveAO,
  title={Selective arrangement of ubiquitinated and D1 protein-containing nucleosomes within the Drosophila genome.},
  author={Louis Levinger and Alexander Varshavsky},
  journal={Cell},
  year={1982},
  volume={28 2},
  pages={375-85}
}
We have a new approach, two-dimensional hybridization mapping of nucleosomes, to compare the structures of mononucleosomes from different regions of the Drosophila melanogaster genome. Approximately one in two nucleosomes of the transcribed copia and heat-shock 70 (hsp 70) genes in nonshocked cultured cells contains ubiquitin-H2A (uH2A) semihistone, a covalent conjugate of histone H2A and a small protein, ubiquitin. In striking contrast, less than one in 25 nucleosomes of tandemly repeated… CONTINUE READING