Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody

  title={Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody},
  author={Jun Ogasawara and Takashi Suda and Shigekazu Nagata},
  journal={The Journal of Experimental Medicine},
  pages={485 - 491}
Fas is a cell surface protein that mediates apoptosis. A mouse mutant, lpr (lymphoproliferation), has a mutation in the Fas gene. In this report, we studied the expression and function of Fas in various subpopulations of mouse thymocytes. Abundant expression of Fas was detected on CD4+CD8+ double positive as well as CD4+ or CD8+ single positive thymocytes in wild-type mice. Little or low levels of Fas were expressed in CD4-CD8- double negative thymocytes except for the CD4-CD8-CD3+ phenotype… CONTINUE READING
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