Selective apoptosis in hepatic stellate cells mediates the antifibrotic effect of phenanthrenes from Dendrobium nobile.

@article{Yang2012SelectiveAI,
  title={Selective apoptosis in hepatic stellate cells mediates the antifibrotic effect of phenanthrenes from Dendrobium nobile.},
  author={Hyekyung Yang and Phil-jun Lee and Eun Ju Jeong and Hong Pyo Kim and Young Choong Kim},
  journal={Phytotherapy research : PTR},
  year={2012},
  volume={26 7},
  pages={
          974-80
        }
}
Regardless of the etiology, cellular death of the liver parenchymal hepatocyte seems to be a primary event of hepatic fibrogenesis, which ultimately results in hepatic stellate cell (HSC) activation and the synthesis of extracellular matrix proteins. Recently it has been demonstrated that hepatic fibrosis can be a reversible process when the stimulus is properly eliminated. Apoptotic removal of active HSC is considered an essential part of the resolution. By employing the HSC cell line, HSC-T6… CONTINUE READING
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