Selective antagonists of benzodiazepines

@article{Hunkeler1981SelectiveAO,
  title={Selective antagonists of benzodiazepines},
  author={Walter Hunkeler and Hanns Möhler and Lorenzo Pieri and Petar Polc and Erico P. Bonetti and R. Cumin and Rudolf Schaffner and Willy E. Haefely},
  journal={Nature},
  year={1981},
  volume={290},
  pages={514-516}
}
Benzodiazepines produce most, if not all, of their numerous effects on the central nervous system (CNS) primarily by increasing the function of those chemical synapses that use γ-amino butyric acid (GABA) as transmitter1,2. This specific enhancing effect on GABAergic synaptic inhibition is initiated by the interaction of benzodiazepines with membrane proteins of certain central neurones, to which drugs of this chemical class bind with high affinity and specificity3,4. The molecular processes… 
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