Selective antagonist activity of 5-aminohex-2-enedioic acid on amino acid excitation of cat spinal neurones.

@article{Allan1980SelectiveAA,
  title={Selective antagonist activity of 5-aminohex-2-enedioic acid on amino acid excitation of cat spinal neurones.},
  author={Robin D. Allan and Joel C Bornstein and Dr. Robin Curtis and Graham A. R. Johnston and David Lodge},
  journal={Neuroscience letters},
  year={1980},
  volume={16 1},
  pages={17-20}
}
D- and L-5-aminohex-2-enedioic acid (AHED) and the DL-2-bromo derivative, which are conformationally restricted analogues of the excitatory amino acid antagonist D-alpha-aminoadipic acid (D alpha AA), were tested microelectrophoretically on cat spinal neurones. D-AHED reduced the excitatory action of N-methyl-D-aspartate (NMDA) to a greater extent than that… CONTINUE READING