Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons

@article{Paternain1995SelectiveAO,
  title={Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons},
  author={Ana V. Paternain and Miguel Morales and Juan Lerma},
  journal={Neuron},
  year={1995},
  volume={14},
  pages={185-189}
}
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369 Citations
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369 Citations

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Activation and Desensitization of Hippocampal Kainate Receptors
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Kainate receptors in hippocampal CA3 subregion: evidence for a role in regulating neurotransmitter release
Developmental and activity- dependent regulation of kainate receptors at thalamocortical synapses
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It is shown that developing thalamocortical synapses express postsynaptic kainate receptors as well as AMPA receptors; however, the two receptor subtypes do not co-localize.
The physiological role of kainate receptors in the amygdala
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Findings have suggested a prominent role of GLUk5-containing kainate receptors in the regulation of neuronal excitability in the amygdala.
Acute effects of ethanol on kainate receptors in cultured hippocampal neurons.
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The present results suggest that kainate receptors are important targets for the actions of ethanol in the central nervous system.
Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons
TLDR
It is reported that repetitive activation of the hippocampal mossy fibre pathway, which is associated with high-affinity kainate binding and many of the kainATE receptor subtypes, generates a slow excitatory synaptic current with all of the properties expected of a kainates receptor.
Glutamate Receptor Subunits GluR5 and KA-2 Are Coexpressed in Rat Trigeminal Ganglion Neurons
TLDR
The data suggest that the heteromeric GluR5/KA2 combination actually occurs in TG neurons and give a clue as to the subunit composition of native kainate receptor channels.
Attenuated Plasticity of Postsynaptic Kainate Receptors in Hippocampal CA3 Pyramidal Neurons
TLDR
The data suggest that the proportional contribution of AMPA and kainate receptors to ensemble synaptic currents will vary depending on the firing frequency of mossy fiber afferents, which has been shown to be involved in seizurogenic firing of the CA3 network.
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