Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons

  title={Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons},
  author={Ana V. Paternain and Miguel Morales and Juan Lerma},

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The synaptic activation of kainate receptors
It is demonstrated that high-frequency stimulation of mossy fibres in rat hippocampal slices, in the presence of the highly selective AMPA receptor antagonist GYKI 53655, plus NMDA- and GABA-receptor antagonists, activates an inward current in CA3 neurons that has a pharmacology typical of kainate receptors.
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  • W. Wisden, P. Seeburg
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1993
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