Selective antagonism at dopamine D3 receptors attenuates cocaine-seeking behaviour in the rat.

@article{Cervo2007SelectiveAA,
  title={Selective antagonism at dopamine D3 receptors attenuates cocaine-seeking behaviour in the rat.},
  author={Luigi Cervo and Arianna Cocco and Cinzia Petrella and Christian A. Heidbreder},
  journal={The international journal of neuropsychopharmacology},
  year={2007},
  volume={10 2},
  pages={167-81}
}
Dopamine (DA) D3 receptors have been suggested to play a role in mechanisms underlying the ability of drug-associated cues to induce drug-seeking behaviour. The present study investigated whether SB-277011-A, a selective DA D3 receptor antagonist, modulates reinstatement of cocaine-seeking behaviour induced by cocaine-associated stimuli. The study also explored whether or not this modulation is generable to seeking behaviours associated with a nutritive reinforcer such as sucrose. Separate… CONTINUE READING