Selective and time related activation of the cardiac renin-angiotensin system after experimental heart failure: relation to ventricular function and morphology.

@article{Pinto1993SelectiveAT,
  title={Selective and time related activation of the cardiac renin-angiotensin system after experimental heart failure: relation to ventricular function and morphology.},
  author={Yigal M. Pinto and Bart JGL de Smet and Wiek H van Gilst and E. Scholtens and Stefan H J Monnink and Pieter A. de Graeff and Harry Wesseling},
  journal={Cardiovascular research},
  year={1993},
  volume={27 11},
  pages={1933-8}
}
OBJECTIVE The cardiac renin-angiotensin system is activated in experimental heart failure, but it is unknown at what stage of heart failure it becomes activated, and whether activation is related to ventricular dysfunction and dilatation. Changes in activity of cardiac, renal, and plasma angiotensin converting enzyme (ACE) were therefore examined at different stages of experimental heart failure, with simultaneous measurements of left ventricular pressure, systolic dP/dt, and inner ventricular… CONTINUE READING

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