Selective and potent analgetics derived from cannabinoids.

@article{Johnson1981SelectiveAP,
  title={Selective and potent analgetics derived from cannabinoids.},
  author={Martin R. Johnson and Lawrence S. Melvin and T H Althuis and J. S. Bindra and C A Harbert and George Milne and Albert Weissman},
  journal={Journal of clinical pharmacology},
  year={1981},
  volume={21 S1},
  pages={
          271S-282S
        }
}
Based on the hypothesis that analgetic activity is a dissociable feature of the cannabinoid molecule, we examined modifications of the side chain, the phenolic moiety, and, most significantly, structures that lack the benzopyran functionality present in THC and (--)-9-nor-9 beta-hydroxyhexahydrocannabinol (HHC). A new grouping, the 1-methyl-4-phenylbutyloxy C-3 side chain, elaborates a unique lipopholic region. Replacement of the phenol substituent produced several derivatives which retain… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Title : Characterization of an Amphibian Cannabinoid Receptor

Thomas F. rray
2012
View 19 Excerpts
Highly Influenced

Drugs of abuse: chemistry, pharmacology, immunology, and AIDS. Introduction.

NIDA research monograph • 1990
View 16 Excerpts
Highly Influenced

Interactions of Cannabinoids With Biochemical Substrates

Substance abuse : research and treatment • 2017
View 3 Excerpts

Endocannabinoids and obesity.

Vitamins and hormones • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…