Selective and potent analgetics derived from cannabinoids.

  title={Selective and potent analgetics derived from cannabinoids.},
  author={Martin R. Johnson and Lawrence S. Melvin and T H Althuis and J. S. Bindra and C A Harbert and George Milne and Albert Weissman},
  journal={Journal of clinical pharmacology},
  volume={21 S1},
Based on the hypothesis that analgetic activity is a dissociable feature of the cannabinoid molecule, we examined modifications of the side chain, the phenolic moiety, and, most significantly, structures that lack the benzopyran functionality present in THC and (--)-9-nor-9 beta-hydroxyhexahydrocannabinol (HHC). A new grouping, the 1-methyl-4-phenylbutyloxy C-3 side chain, elaborates a unique lipopholic region. Replacement of the phenol substituent produced several derivatives which retain… CONTINUE READING

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