Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.

@article{Mimura2014SelectiveAP,
  title={Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.},
  author={Naoya Mimura and Teru Hideshima and Toshiyasu Shimomura and Rikio Suzuki and Hiroto Ohguchi and Ola Rizq and Shohei Kikuchi and Yasuhiro Yoshida and Francesca Cottini and Jana Jakubikova and Diana Cirstea and Gullu T Gorgun and Jiro Minami and Yu-Tzu Tai and Paul G Richardson and Teruhiro Utsugi and Atsushi Iwama and Kenneth C. Anderson},
  journal={Cancer research},
  year={2014},
  volume={74 16},
  pages={4458-69}
}
The PI3K/Akt pathway plays a crucial role in the pathogenesis of multiple myeloma (MM) in the bone marrow (BM) milieu. However, efficacy of selective and potent Akt inhibition has not yet been fully elucidated. In this study, we, therefore, examined the biologic impact of selective and potent Akt inhibition by a novel allosteric inhibitor TAS-117. TAS-117 induced significant growth inhibition, associated with downregulation of phosphorylated Akt (p-Akt), selectively in MM cell lines with high… CONTINUE READING