Selective and nonselective toxicity of TRAIL/Apo2L combined with chemotherapy in human bone tumour cells vs. normal human cells.

@article{Valen2003SelectiveAN,
  title={Selective and nonselective toxicity of TRAIL/Apo2L combined with chemotherapy in human bone tumour cells vs. normal human cells.},
  author={Frans van Valen and Simone Fulda and K D Schaefer and Borna Truckenbrod and Marc Hotfilder and Christopher Poremba and K -M Debatin and Winfried Winkelmann},
  journal={International journal of cancer},
  year={2003},
  volume={107 6},
  pages={929-40}
}
Although TRAIL/Apo2L preferably induces apoptosis in tumour cells without toxicity in normal cells, many tumour cell types display TRAIL/Apo2L resistance. Whether TRAIL/Apo2L in combination with chemotherapy may overcome TRAIL/Apo2L resistance while maintaining tumour selectivity remains to be determined. Here, we report that while ActD, DOX and CDDP sensitised both OS and Ewing's tumour cell lines and normal cells (hOBs, synovial cells, fibroblasts) to TRAIL/Apo2L-induced apoptosis, the… CONTINUE READING