Selective and hyperactive uptake of foreign DNA by adaptive immune systems of an archaeon via two distinct mechanisms

@inproceedings{Erdmann2012SelectiveAH,
  title={Selective and hyperactive uptake of foreign DNA by adaptive immune systems of an archaeon via two distinct mechanisms},
  author={Susanne Erdmann and Roger A. Garrett},
  booktitle={Molecular microbiology},
  year={2012}
}
Central to the disparate adaptive immune systems of archaea and bacteria are clustered regularly interspaced short palindromic repeats (CRISPR). The spacer regions derive from invading genetic elements and, via RNA intermediates and associated proteins, target and cleave nucleic acids of the invader. Here we demonstrate the hyperactive uptake of hundreds of unique spacers within CRISPR loci associated with type I and IIIB immune systems of a hyperthermophilic archaeon. Infection with an… CONTINUE READING

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