Selective and Shared Contributions of the Hippocampus and Perirhinal Cortex to Episodic Item and Associative Encoding

@article{Staresina2008SelectiveAS,
  title={Selective and Shared Contributions of the Hippocampus and Perirhinal Cortex to Episodic Item and Associative Encoding},
  author={Bernhard P. Staresina and Lila Davachi},
  journal={Journal of Cognitive Neuroscience},
  year={2008},
  volume={20},
  pages={1478-1489}
}
Although the general role of the medial-temporal lobe (MTL) in episodic memory is well established, controversy surrounds the precise division of labor between distinct MTL subregions. The perirhinal cortex (PrC) has been hypothesized to support nonassociative item encoding that contributes to later familiarity, whereas the hippocampus supports associative encoding that selectively contributes to later recollection. However, because previous paradigms have predominantly used recollection of the… 
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  • 2008
TLDR
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TLDR
It is suggested that MTL subfields contribute uniquely to the formation of memories that endure over time, and highlight a role for PRC in supporting subsequent durable episodic recollection.
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The results strongly point to representational domain as a key factor determining the involvement of different MTLC subregions during successful episodic memory formation.
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While it has been established that the medial temporal lobe (MTL) is critical for successful memory formation, the precise contribution of one of the key MTL subregions, the perirhinal cortex (PrC),
Medial Temporal Lobe Activity during Source Retrieval Reflects Information Type, not Memory Strength
TLDR
Results showed that encoding color information as an item detail improved source recognition in amnesic patients with recollection deficits, and qualitatively different patterns of results observed in PRc and hippocampus/PHc are consistent with the idea that different MTL regions process different types of episodic information.
Consolidation of Associative and Item Memory Is Related to Post-Encoding Functional Connectivity between the Ventral Tegmental Area and Different Medial Temporal Lobe Subregions during an Unrelated Task
TLDR
High-resolution fMRI in humans found that the strength of post-encoding functional connectivity between the VTA and CA1 selectively correlated with long-term associative memory, despite subjects actively engaging in an unrelated task during this period.
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