Selective and Shared Contributions of the Hippocampus and Perirhinal Cortex to Episodic Item and Associative Encoding

  title={Selective and Shared Contributions of the Hippocampus and Perirhinal Cortex to Episodic Item and Associative Encoding},
  author={Bernhard P. Staresina and Lila Davachi},
  journal={Journal of Cognitive Neuroscience},
Although the general role of the medial-temporal lobe (MTL) in episodic memory is well established, controversy surrounds the precise division of labor between distinct MTL subregions. The perirhinal cortex (PrC) has been hypothesized to support nonassociative item encoding that contributes to later familiarity, whereas the hippocampus supports associative encoding that selectively contributes to later recollection. However, because previous paradigms have predominantly used recollection of the… 
Content-specific source encoding in the human medial temporal lobe.
  • T. Awipi, L. Davachi
  • Psychology, Biology
    Journal of experimental psychology. Learning, memory, and cognition
  • 2008
It was found that encoding activation in the right perirhinal cortex correlates with successful recollection of the paired object, and other MTL subregions also exhibited content-specific source encoding patterns of activation, suggesting that MTL subsequent memory effects are sensitive to stimulus category.
Contributions of the hippocampal subfields and entorhinal cortex to disambiguation during working memory
It is suggested that CA3/DG, CA1 and the subiculum support the disambiguation and encoding of overlapping representations while CA1,Subiculum and entorhinal cortex maintain these overlapping representations during working memory.
Neural Activity in the Hippocampus and Perirhinal Cortex during Encoding Is Associated with the Durability of Episodic Memory
It is suggested that MTL subfields contribute uniquely to the formation of memories that endure over time, and highlight a role for PRC in supporting subsequent durable episodic recollection.
Perirhinal and Parahippocampal Cortices Differentially Contribute to Later Recollection of Object- and Scene-Related Event Details
The results strongly point to representational domain as a key factor determining the involvement of different MTLC subregions during successful episodic memory formation.
The role of recollection and familiarity in the functional differentiation of the medial temporal lobes
There has been disagreement about whether recall/recollection is primarily mediated by the hippocampus and familiarity by the evolutionarily newer MTL cortices or whether the MTL mediates these kinds of memory in an integrated, homogeneous fashion.
Object Unitization and Associative Memory Formation Are Supported by Distinct Brain Regions
While it has been established that the medial temporal lobe (MTL) is critical for successful memory formation, the precise contribution of one of the key MTL subregions, the perirhinal cortex (PrC),
Medial Temporal Lobe Activity during Source Retrieval Reflects Information Type, not Memory Strength
Results showed that encoding color information as an item detail improved source recognition in amnesic patients with recollection deficits, and qualitatively different patterns of results observed in PRc and hippocampus/PHc are consistent with the idea that different MTL regions process different types of episodic information.
Consolidation of Associative and Item Memory Is Related to Post-Encoding Functional Connectivity between the Ventral Tegmental Area and Different Medial Temporal Lobe Subregions during an Unrelated Task
High-resolution fMRI in humans found that the strength of post-encoding functional connectivity between the VTA and CA1 selectively correlated with long-term associative memory, despite subjects actively engaging in an unrelated task during this period.


Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories
This work used event-related functional MRI to examine the relation between activation in distinct medial temporal lobe subregions during memory formation and the ability to later recognize an item as previously encountered and later recollect specific contextual details about the prior encounter.
The medial temporal lobe and recognition memory.
Evidence from neuropsychological, neuroimaging, and neurophysiological studies of humans, monkeys, and rats indicates that different subregions of the MTL make distinct contributions to recollection and familiarity; the data suggest that the hippocampus is critical for recollection but not familiarity.
Medial temporal lobe activation during encoding and retrieval of novel face-name pairs
Functional magnetic resonance imaging is used to measure brain activity during learning and later recognition testing of novel face‐name pairs and shows that there is greater activity for successful encoding of associative information than for non‐associative information in the right hippocampal region, as well as in the left amygdala and right parahippocampal cortex.
Item, context and relational episodic encoding in humans
  • L. Davachi
  • Psychology, Biology
    Current Opinion in Neurobiology
  • 2006
The medial temporal lobe.
This analysis draws on studies of human memory impairment and animal models of memory impairment, as well as neurophysiological and neuroimaging data, to show that this system is principally concerned with memory and operates with neocortex to establish and maintain long-term memory.