Selective and Quickly Reversible Inactivation of Mammalian Neurons In Vivo Using the Drosophila Allatostatin Receptor

@article{Tan2006SelectiveAQ,
  title={Selective and Quickly Reversible Inactivation of Mammalian Neurons In Vivo Using the Drosophila Allatostatin Receptor},
  author={Elaine Yu Ming Tan and Yoshiaki Yamaguchi and Gregory D. Horwitz and Simon Gosgnach and Edward S. Lein and Martyn Goulding and T. D. Albright and Edward M. Callaway},
  journal={Neuron},
  year={2006},
  volume={51},
  pages={157-170}
}
Genetic strategies for perturbing activity of selected neurons hold great promise for understanding circuitry and behavior. Several such strategies exist, but there has been no direct demonstration of reversible inactivation of mammalian neurons in vivo. We previously reported quickly reversible inactivation of neurons in vitro using expression of the Drosophila allatostatin receptor (AlstR). Here, adeno-associated viral vectors are used to express AlstR in vivo in cortical and thalamic neurons… CONTINUE READING

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