Selective amplification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large tag transgenic mice.

@article{Schirmacher1991SelectiveAO,
  title={Selective amplification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large tag transgenic mice.},
  author={Peter Schirmacher and Wffliam A. Held and Dajun Yang and Luis Biempica and Charles E. Rogler},
  journal={The American journal of pathology},
  year={1991},
  volume={139 1},
  pages={231-41}
}
In a major urinary protein (MUP)-promoter/simian virus 40 (SV40)Tag transgenic mouse line (MT-D2) the liver-directed, androgen-regulated transgene expression leads to synchronized pathology resulting in a stepwise progression to multiple hepatocellular carcinomas. SV40Tag-activated replication gives rise to two different preneoplastic alterations in… CONTINUE READING