Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene.

@article{Wood2000SelectiveAI,
  title={Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene.},
  author={Teresa L. Wood and Leslie E. Rogler and Maureen E. Czick and Alwin G. Schuller and John E. Pintar},
  journal={Molecular endocrinology},
  year={2000},
  volume={14 9},
  pages={
          1472-82
        }
}
Insulin-like growth factor binding protein 2 (IGFBP-2) is one member of the family of IGF binding proteins believed to have both endocrine functions elicited by modulating serum IGF half-life and transport as well as autocrine/paracrine functions that result from blocking or enhancing the availability of IGFs to bind cell surface receptors. To clarify the in vivo role of IGFBP-2, we have used gene targeting to introduce a null IGFBP-2 allele into the mouse genome. Animals homozygous for the… 
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Functional consequences of IGFBP excess—lessons from transgenic mice
TLDR
Phenotypic analysis revealed features that are common for most IGFBPs (growth inhibition), but also effects that appear to be specific for some but not all IGFBBP, such as disturbed glucose homeostasis or impaired fertility.
Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice
  • D. Salih, G. Tripathi, +6 authors J. Pell
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
Although growth retardation was obvious prenatally, maximal inhibition occurred postnatally before the onset of growth hormone-dependent growth, regardless of Igfbp5 expression level, revealing a period of sensitivity to IGFBP-5 during this important stage of tissue programming.
Growth Inhibition in Giant Growth Hormone Transgenic Mice by Overexpression of Insulin-Like Growth Factor-Binding Protein-2.
TLDR
IGFBP-2 levels were highest in pancreas, followed by skeletal muscle, heart, kidney, brain,skin, skin, and spleen, and no elevation of IGF BP-2 wa... no elevation in tissue IGFBP- 2 levels between B and GB mice.
Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2.
TLDR
This study demonstrates, for the first time, the potential of IGFBP-2 to inhibit GH-stimulated growth in giant transgenic mice, providing further evidence for an inhibitory effect of this IGFBP in vivo.
Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5.
TLDR
Combinational IGFBP KO mice generated provide direct evidence for combinatorial effects of IGFBP-3, -4, and -5 in both metabolism and at least some soft tissues and strongly suggest overlapping roles for IGF BP-3 and-5 in maintaining IGF-I-mediated postnatal growth in mice.
Delayed mammary gland involution in mice with mutation of the insulin-like growth factor binding protein 5 gene.
TLDR
It is demonstrated that IGFBP-5, although not essential for normal growth, is required for normal mammary gland involution and can regulate Mammary gland morphogenesis in response to hormone stimulation.
Minireview: Insights from Insulin-Like Growth Factor Binding Protein Transgenic Mice
TLDR
This review examines the data reported to date for transgenic mouse models that overexpress IGFBPs and examines the effect of generalized or tissue-specific overexpression on the functional role of the circulating IGFs and the originally proposed endocrine somatomedin hypothesis.
Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice.
TLDR
In conclusion, overexpression of IGFBP-4 inhibits growth of the thymus and is a potential growth inhibitor of lymphoid tissues.
Functional analysis of insulin-like growth factor binding protein -4 and -6 in transgenic mice
TLDR
It is revealed that overexpression of IGFBP-4 had no significant effect on the postnatal body and organ growth, except that the weight and volume of thymus in 8- and 12-week-old transgenic mice were significantly reduced compared to the controls.
Targeted knockdown of insulin-like growth factor binding protein-2 disrupts cardiovascular development in zebrafish embryos.
TLDR
It is suggested that IGFBP-2 is required for general embryonic development and growth and plays a local role in regulating vascular development in a model vertebrate organism.
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References

SHOWING 1-10 OF 89 REFERENCES
Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth.
TLDR
Elevated IGF-II in postnatal life has multiple endocrine consequences and subtle time-specific effects on organ growth, and is a major regulator of IGFBP-2.
Tissue-specific expression of the insulin-like growth factor binding protein (IGFBP) mRNAs in mouse and rat development
Different tissue distribution and hormonal regulation of messenger RNAs encoding rat insulin-like growth factor-binding proteins-1 and -2.
TLDR
It is demonstrated that expression of mRNAs encoding the two BPs differs in some fetal rat tissues and in the livers of adult rats after hypophysectomy, fasting, or streptozotocin-induced diabetes.
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
TLDR
Germ-line transmission of the inactivated IGF-II gene from male chimaeras yielded heterozygous progeny that were smaller than their ES cell-derived wild-type littermates (about 60% of normal body weight) and these growth-deficient animals were otherwise apparently normal and fertile.
Distinct expression patterns of insulin-like growth factor binding proteins 2 and 5 during fetal and postnatal development.
TLDR
Examination of expression of a recently described IGFBP gene in the rat embryo and fetus and in selected adult tissues suggests functions for IGFBP-5 during development of several organ systems.
Role of insulin-like growth factors in embryonic and postnatal growth
IGF-I is required for normal embryonic growth in mice.
TLDR
IGF-I appears to be essential for correct embryonic development in mice and is reported to affect linear growth, glucose metabolism, organ homeostasis, and the immune and neurologic systems.
Cellular distribution of insulin-like growth factor binding protein mRNAs and peptides during rat lung development.
TLDR
The widespread distribution of IGFBP immunoreactivity compared with their respective mRNAs suggests that IGFBPs are important paracrine factors in the regulation of IGF action in the developing lung.
Tissue, developmental, and metabolic regulation of messenger ribonucleic acid encoding a rat insulin-like growth factor-binding protein.
TLDR
RIGFBP-2 may play a homeostatic role during catabolic states in the adult rat after hypophysectomy or fasting, and both mRNAs are more abundant in fetal tissues than in the corresponding tissues from adult rats.
IGF-binding protein mRNAs in the human fetus: tissue and cellular distribution of developmental expression.
TLDR
These studies indicate that IGFBPs are important paracrine modulators of IGF action on cellular growth and differentiation, by modulating IGF-dependent or IGF-independent actions.
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