Selective alkylation of nucleic acids by carcinogens may cause miscoding in DNA. A theoretical study.

Abstract

The CNDO/II method was used to study the pairing abilities of various alkylated nucleic acids. On the basis of these results, a mechanism for mutation (carcinogenesis) is proposed. Our calculations suggest that O-(6) alkylated guanine and/or O-(4) alkylated thymine could cause miscoding during the replication of DNA.

Cite this paper

@article{Klopman1982SelectiveAO, title={Selective alkylation of nucleic acids by carcinogens may cause miscoding in DNA. A theoretical study.}, author={Gilles Klopman and Akshay Ray}, journal={Cancer biochemistry biophysics}, year={1982}, volume={6 1}, pages={31-5} }