Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries.

@article{Pinilla2013SelectiveAA,
  title={Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries.},
  author={Clemencia Pinilla and Bruce S. Edwards and Jon R. Appel and Tina Yates-Gibbins and Marc A. Giulianotti and Jos{\'e} L. Medina-Franco and S. Michelle Young and Radleigh Santos and Larry A. Sklar and Richard A. Houghten},
  journal={Molecular pharmacology},
  year={2013},
  volume={84 3},
  pages={314-24}
}
The formylpeptide receptor (FPR1) and formylpeptide-like 1 receptor (FPR2) are G protein-coupled receptors that are linked to acute inflammatory responses, malignant glioma stem cell metastasis, and chronic inflammation. Although several N-formyl peptides are known to bind to these receptors, more selective small-molecule, high-affinity ligands are needed for a better understanding of the physiologic roles played by these receptors. High-throughput assays using mixture-based combinatorial… CONTINUE READING

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Scanning structure-activity relantionships in combinatorial data sets: Rapid identification of activity-switches

JL Medina-Franco, C Pinilla, +6 authors RA Houghten
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