Selective advantages created by codon ambiguity allowed for the evolution of an alternative genetic code in Candida spp.

@article{Santos1999SelectiveAC,
  title={Selective advantages created by codon ambiguity allowed for the evolution of an alternative genetic code in Candida spp.},
  author={M. A. Santos and C. Cheesman and V. Costa and P. Moradas-Ferreira and M. Tuite},
  journal={Molecular microbiology},
  year={1999},
  volume={31 3},
  pages={
          937-47
        }
}
  • M. A. Santos, C. Cheesman, +2 authors M. Tuite
  • Published 1999
  • Medicine, Biology
  • Molecular microbiology
  • Several species of the genus Candida decode the standard leucine CUG codon as serine. This and other deviations from the standard genetic code in both nuclear and mitochondrial genomes invalidate the notion that the genetic code is frozen and universal and prompt the questions 'why alternative genetic codes evolved and, more importantly, how can an organism survive a genetic code change?' To address these two questions, we have attempted to reconstruct the early stages of Candida albicans CUG… CONTINUE READING
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