Corpus ID: 11555345

Selective activation of some dihydrodiols of several polycyclic aromatic hydrocarbons to mutagenic products by prostaglandin synthetase.

@article{Guthrie1982SelectiveAO,
  title={Selective activation of some dihydrodiols of several polycyclic aromatic hydrocarbons to mutagenic products by prostaglandin synthetase.},
  author={J. Guthrie and I. G. Robertson and E. Zeiger and J. Boyd and T. Eling},
  journal={Cancer research},
  year={1982},
  volume={42 5},
  pages={
          1620-3
        }
}
The ability of prostaglandin synthetase (PGS) to cooxidize benzo(a)pyrene, benzo(a)anthracene, chrysene, and several of their dihydrodiol derivatives to mutagenic products was tested with Salmonella typhimurium strains TA98 and TA100. The microsomal fraction of ram seminal vesicles, a known source of PGS, in the presence of the PGS substrate arachidonic acid, metabolized benzo(a)pyrene-7,8-dihydrodiol, benzo(a)anthracene-3,4-dihydrodiol, and chrysene-1,2-dihydrodiol to mutagenic products. This… Expand
Bioactivation of xenobiotics by prostaglandin H synthase.
Prostacyclin is a potent anti-mutagen.
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