Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases.

@article{Kassai2014SelectiveAO,
  title={Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases.},
  author={Hidetoshi Kassai and Yuki Sugaya and Shoko Noda and Kazuki Nakao and Tatsuya Maeda and Masanobu Kano and Atsu Aiba},
  journal={Cell reports},
  year={2014},
  volume={7 5},
  pages={1626-1639}
}
Mammalian target of rapamycin (mTOR) has been implicated in human neurological diseases such as tuberous sclerosis complex (TSC), neurodegeneration, and autism. However, little is known about when and how mTOR is involved in the pathogenesis of these diseases, due to a lack of animal models that directly increase mTOR activity. Here, we generated transgenic mice expressing a gain-of-function mutant of mTOR in the forebrain in a temporally controlled manner. Selective activation of mTORC1 in… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 49 references

Fighting neurodegeneration with rapamycin: mechanistic insights

Nature Reviews Neuroscience • 2011
View 4 Excerpts
Highly Influenced

The tuberous sclerosis complex.

The New England journal of medicine • 2006
View 5 Excerpts
Highly Influenced

http://dx.doi.org/10.1016/j.celrep.2014.04.048 increased mTOR signaling in hypothalamic POMC neurons. Neuron

L. H. Zeng, Y. Ouyang, +8 authors Wong
2014

Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2013
View 2 Excerpts

mTOR in aging, metabolism, and cancer.

Current opinion in genetics & development • 2013
View 1 Excerpt

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