Selective activation of gamma/delta + T cell clones by single anti-CD2 antibodies

@article{Wesselborg1991SelectiveAO,
  title={Selective activation of gamma/delta + T cell clones by single anti-CD2 antibodies},
  author={Sebastian Wesselborg and Ottmar Janssen and Klaus Pechhold and Dieter Kabelitz},
  journal={The Journal of Experimental Medicine},
  year={1991},
  volume={173},
  pages={297 - 304}
}
The CD2 antigen is the target for an "alternative" T cell activation pathway. Numerous studies have demonstrated that pairs of monoclonal antibodies (mAbs) directed toward two different epitopes are required for activation of T cell receptor (TCR)-alpha/beta + T cells via CD2. We have now explored the activation of human TCR-gamma/delta + T cell clones by a panel of anti-CD2 mAbs directed against the sheep erythrocyte-binding (T11.1) epitope of CD2. Seven of seven gamma/delta + clones… CONTINUE READING