Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3

@article{Cogswell2000SelectiveAO,
  title={Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3},
  author={Patricia C. Cogswell and Denis C. Guttridge and William K. Funkhouser and Albert S Baldwin},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={1123-1131}
}
Members of the NF-κB/Rel transcription factor family have been shown recently to be required for cellular transformation by oncogenic Ras and by other oncoproteins and to suppress transformation-associated apoptosis. Furthermore, NF-κB has been shown to be activated by several oncoproteins including HER2/Neu, a receptor tyrosine kinase often expressed in human breast cancer. Human breast cancer cell lines, human breast tumors and normal adjacent tissue were analysed by gel mobility shift assay… CONTINUE READING

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