Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress.


Conditions causing an increase in misfolded or aberrant proteins can impair the activity of the ubiquitin/proteasome system (UPS). This observation is of particular interest, given the fact that proteotoxic stress is closely associated with a large variety of disorders. Although impairment of the UPS appears to be a general consequence of proteotoxic… (More)
DOI: 10.1128/MCB.01485-08


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