Selective ablation of pillar and deiters' cells severely affects cochlear postnatal development and hearing in mice.

@article{Lagarde2013SelectiveAO,
  title={Selective ablation of pillar and deiters' cells severely affects cochlear postnatal development and hearing in mice.},
  author={Marcia M Mellado Lagarde and Brandon C. Cox and Jie Fang and Ruth C. Taylor and Andrew Forge and Jian Zuo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 4},
  pages={1564-76}
}
Mammalian auditory hair cells (HCs) are inserted into a well structured environment of supporting cells (SCs) and acellular matrices. It has been proposed that when HCs are irreversibly damaged by noise or ototoxic drugs, surrounding SCs seal the epithelial surface and likely extend the survival of auditory neurons. Because SCs are more resistant to damage than HCs, the effects of primary SC loss on HC survival and hearing have received little attention. We used the Cre/loxP system in mice to… CONTINUE READING
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