Selective ablation of human T-cell lymphotropic virus type 1 p12I reduces viral infectivity in vivo.

@article{Collins1998SelectiveAO,
  title={Selective ablation of human T-cell lymphotropic virus type 1 p12I reduces viral infectivity in vivo.},
  author={Nathaniel D. Collins and G. C. Newbound and Bjoern Albrecht and John L. Beard and L. S. Ratner and Michael D. Lairmore},
  journal={Blood},
  year={1998},
  volume={91 12},
  pages={4701-7}
}
Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia and HTLV-1-associated myelopathy. Novel, yet conserved RNA transcripts encoded from open reading frames (ORFs) I and II of the viral pX region are expressed both in vitro and in infected individuals. The ORF I mRNA encodes the protein p12(I), which has been shown to localize to cellular endomembranes, cooperate with bovine papillomavirus E5 in transformation, as well as bind to the IL-2 receptor beta… CONTINUE READING

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References

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Showing 1-10 of 35 references

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

Proceedings of the National Academy of Sciences of the United States of America • 1982
View 4 Excerpts
Highly Influenced

Inhibition of human T-cell leukemia virus type 2 Rex function by truncated forms of Rex encoded in alternatively spliced mRNAs

V Ciminale, L Zotti, DM Dagostino, L Chiecobianchi
J Virol 71:2810, • 1997

Human T-cell lymphotropic virus type 1 tax mediates enhanced transcription in CD41 T lymphocytes

GC Newbound, JM Andrews, J Orourke, JN Brady, MD Lairmore
J Virol 70:2101, • 1996

Molecular biology of HTLV-I: Recent progress

M Yoshida
J Acq Immun Defic Synd Hum R 13:S63, • 1996

The human T-cell leukemia/lymphotropic virus type 1 p12 I protein binds the interleukin-2 receptor b and gc chains and affects their expression on the cell surface

JC Mulloy, RW Crowley, J Fullen, WJ Leonard, G Franchini
J Virol 70:3599, • 1996

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