Selective ablation of human T-cell lymphotropic virus type 1 p12I reduces viral infectivity in vivo.

  title={Selective ablation of human T-cell lymphotropic virus type 1 p12I reduces viral infectivity in vivo.},
  author={Nathaniel D. Collins and G. C. Newbound and Bjoern Albrecht and John L. Beard and L. S. Ratner and Michael D. Lairmore},
  volume={91 12},
Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia and HTLV-1-associated myelopathy. Novel, yet conserved RNA transcripts encoded from open reading frames (ORFs) I and II of the viral pX region are expressed both in vitro and in infected individuals. The ORF I mRNA encodes the protein p12(I), which has been shown to localize to cellular endomembranes, cooperate with bovine papillomavirus E5 in transformation, as well as bind to the IL-2 receptor beta… CONTINUE READING


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