Selective Vulnerability of Spinal and Cortical Motor Neuron Subpopulations in delta7 SMA Mice

@inproceedings{dErrico2013SelectiveVO,
  title={Selective Vulnerability of Spinal and Cortical Motor Neuron Subpopulations in delta7 SMA Mice},
  author={Paolo d’Errico and Marina M Boido and Antonio Piras and Valeria Valsecchi and Elena De Amicis and Denise Locatelli and Silvia Capra and Francesco Vagni and Alessandro Vercelli and Giorgio Battaglia},
  booktitle={PloS one},
  year={2013}
}
Loss of the survival motor neuron gene (SMN1) is responsible for spinal muscular atrophy (SMA), the most common inherited cause of infant mortality. Even though the SMA phenotype is traditionally considered as related to spinal motor neuron loss, it remains debated whether the specific targeting of motor neurons could represent the best therapeutic option for the disease. We here investigated, using stereological quantification methods, the spinal cord and cerebral motor cortex of ∆7 SMA mice… CONTINUE READING
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