Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis.

  title={Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis.},
  author={S. Rehberg and Y. Yamamoto and L. Sousse and Eva Bartha and C. Jonkam and A. K. Hasselbach and L. Traber and R. Cox and M. Westphal and P. Enkhbaatar and D. Traber},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={303 10},
  • S. Rehberg, Y. Yamamoto, +8 authors D. Traber
  • Published 2012
  • Medicine
  • American journal of physiology. Heart and circulatory physiology
  • Vasopressin analogs are used as a supplement to norepinephrine in septic shock. The isolated effects of vasopressin agonists on sepsis-induced vascular dysfunction, however, remain controversial. Because V(2)-receptor stimulation induces vasodilation and procoagulant effects, a higher V(1a)- versus V(2)-receptor selectivity might be advantageous. We therefore hypothesized that a sole, titrated infusion of the selective V(1a)-agonist Phe(2)-Orn(8)-Vasotocin (POV) is more effective than the mixed… CONTINUE READING
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