Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis.

@article{Rehberg2012SelectiveVA,
  title={Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis.},
  author={Sebastian Rehberg and Yusuke Yamamoto and Linda E. Sousse and Eva Bartha and Collette C Jonkam and Anthony Karl Hasselbach and Lillian D. Traber and Robert A. Cox and Martin Westphal and Perenlei Enkhbaatar and Daniel Lee Traber},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2012},
  volume={303 10},
  pages={
          H1245-54
        }
}
Vasopressin analogs are used as a supplement to norepinephrine in septic shock. The isolated effects of vasopressin agonists on sepsis-induced vascular dysfunction, however, remain controversial. Because V(2)-receptor stimulation induces vasodilation and procoagulant effects, a higher V(1a)- versus V(2)-receptor selectivity might be advantageous. We therefore hypothesized that a sole, titrated infusion of the selective V(1a)-agonist Phe(2)-Orn(8)-Vasotocin (POV) is more effective than the mixed… CONTINUE READING
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