Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis.

@article{Rehberg2012SelectiveVA,
  title={Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis.},
  author={S. Rehberg and Y. Yamamoto and L. Sousse and Eva Bartha and C. Jonkam and A. K. Hasselbach and L. Traber and R. Cox and M. Westphal and P. Enkhbaatar and D. Traber},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2012},
  volume={303 10},
  pages={
          H1245-54
        }
}
  • S. Rehberg, Y. Yamamoto, +8 authors D. Traber
  • Published 2012
  • Medicine
  • American journal of physiology. Heart and circulatory physiology
  • Vasopressin analogs are used as a supplement to norepinephrine in septic shock. The isolated effects of vasopressin agonists on sepsis-induced vascular dysfunction, however, remain controversial. Because V(2)-receptor stimulation induces vasodilation and procoagulant effects, a higher V(1a)- versus V(2)-receptor selectivity might be advantageous. We therefore hypothesized that a sole, titrated infusion of the selective V(1a)-agonist Phe(2)-Orn(8)-Vasotocin (POV) is more effective than the mixed… CONTINUE READING
    A Selective V1A Receptor Agonist, Selepressin, Is Superior to Arginine Vasopressin and to Norepinephrine in Ovine Septic Shock*
    • 47
    • Highly Influenced
    • PDF
    Iatrogenic salt water drowning and the hazards of a high central venous pressure
    • 113
    • Highly Influenced
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 60 REFERENCES
    Role of selective V2-receptor-antagonism in septic shock: a randomized, controlled, experimental study
    • 17
    Role of selective V1a receptor agonism in ovine septic shock*
    • 33
    Beneficial Effects of Short-term Vasopressin Infusion during Severe Septic Shock
    • 501
    • PDF
    Arginine Vasopressin in Advanced Vasodilatory Shock: A Prospective, Randomized, Controlled Study
    • 461
    • PDF
    Vasopressin versus norepinephrine infusion in patients with septic shock.
    • 979
    • PDF
    Arginine vasopressin in 316 patients with advanced vasodilatory shock*
    • 186