Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions.

Abstract

Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and counterregulator of glucocorticoids, is a potential therapeutic target. MIF is markedly different from other cytokines because it is constitutively expressed, stored in the cytoplasm, and present in the circulation of healthy subjects. Thus, the concept of targeting MIF for… (More)
DOI: 10.4049/jimmunol.1500572

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@article{Thiele2015SelectiveTO, title={Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions.}, author={Michael Thiele and Randolf J. Kerschbaumer and Frederick W. K. Tam and Dirk V{\"{o}lkel and Patrice Douillard and Alexander Schinagl and Harald K{\"{u}hnel and Jennifer A. Smith and John Patrick McDaid and Gurjeet Bhangal and Mei-Ching Yu and Charles Dickson Pusey and H Terence Cook and Josef Kovarik and Erica M Magelky and Atul K. Bhan and Manfred Rieger and Geert C. Mudde and Hartmut J. Ehrlich and Bernd Jilma and Herbert Tilg and Alexander Rupert Moschen and Cox Terhorst and Friedrich Scheiflinger}, journal={Journal of immunology}, year={2015}, volume={195 5}, pages={2343-52} }