Selective Targeting of TRPV1 Expressing Sensory Nerve Terminals in the Spinal Cord for Long Lasting Analgesia

@inproceedings{Jeffry2009SelectiveTO,
  title={Selective Targeting of TRPV1 Expressing Sensory Nerve Terminals in the Spinal Cord for Long Lasting Analgesia},
  author={Joseph A. Jeffry and Shuang-Quan Yu and Parul Sikand and Arti Parihar and Miles Steven Evans and Louis S. Premkumar},
  booktitle={PloS one},
  year={2009}
}
Chronic pain is a major clinical problem and opiates are often the only treatment, but they cause significant problems ranging from sedation to deadly respiratory depression. Resiniferatoxin (RTX), a potent agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), causes a slow, sustained and irreversible activation of TRPV1 and increases the frequency of spontaneous excitatory postsynaptic currents, but causes significant depression of evoked EPSCs due to nerve terminal depolarization block… CONTINUE READING

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