Selective Targeting of Newly Synthesized Arc mRNA to Active Synapses Requires NMDA Receptor Activation

@article{Steward2001SelectiveTO,
  title={Selective Targeting of Newly Synthesized Arc mRNA to Active Synapses Requires NMDA Receptor Activation},
  author={O. Steward and P. Worley},
  journal={Neuron},
  year={2001},
  volume={30},
  pages={227-240}
}
  • O. Steward, P. Worley
  • Published 2001
  • Medicine, Biology
  • Neuron
  • Newly synthesized Arc mRNA is selectively targeted to synapses that have experienced particular patterns of activity. Here, we demonstrate that the targeting requires NMDA receptor activation. Arc expression was induced by an electroconvulsive seizure, and the newly synthesized mRNA was then targeted to synaptic sites by activating the perforant path projections to the dentate gyrus. When micropipette electrodes containing NMDA receptor antagonists (MK801 or APV) were positioned in the dentate… CONTINUE READING
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