Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window.

@article{Dreyfus2010SelectiveTC,
  title={Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window.},
  author={Fanny M Dreyfus and Anne Tscherter and Adam C Errington and John Renger and Hee-sup Shin and Victor N. Uebele and Vincenzo Crunelli and R{\'e}gis C Lambert and Nathalie Leresche},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 1},
  pages={
          99-109
        }
}
Although it is well established that low-voltage-activated T-type Ca(2+) channels play a key role in many neurophysiological functions and pathological states, the lack of selective and potent antagonists has so far hampered a detailed analysis of the full impact these channels might have on single-cell and neuronal network excitability as well as on Ca(2+) homeostasis. Recently, a novel series of piperidine-based molecules has been shown to selectively block recombinant T-type but not high… CONTINUE READING

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