Selective T-Type Calcium Channel Blockade Alleviates Hyperalgesia in ob/ob Mice

@inproceedings{Latham2009SelectiveTC,
  title={Selective T-Type Calcium Channel Blockade Alleviates Hyperalgesia in ob/ob Mice},
  author={Janelle R. Latham and Sriyani Pathirathna and Miljen M. Jagodic and Won Joo Choe and Michaela E. Levin and Michael T. Nelson and Woo Yong Lee and K. Amrutha Krishnan and Douglas F Covey and Slobodan M Todorovic and Vesna Jevtovi{\'c}-Todorovi{\'c}},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE Morbid obesity may be accompanied by diabetes and painful diabetic neuropathy, a poorly understood condition that is manifested by mechanical or thermal allodynia and hyperalgesia. Recent studies have highlighted the importance of T-type calcium channels (T-channels) in peripheral nociception; therefore, our goal was to examine the function of these channels in the pathophysiology and development of painful diabetic neuropathy. RESEARCH DESIGN AND METHODS In vivo testing of… CONTINUE READING

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