Selective Serotonin Reuptake Inhibitors for Premenstrual Dysphoric Disorder

  title={Selective Serotonin Reuptake Inhibitors for Premenstrual Dysphoric Disorder},
  author={Teri B. Pearlstein},
There have been a large number of studies conducted investigating the use of selective serotonin reuptake inhibitors (SSRIs) in the treatment of patients with premenstrual dysphoric disorder (PMDD). The 12 randomised, controlled trials with continuous dose administration of SSRIs and the eight randomised, controlled trials with luteal phase dose administration (from ovulation to menses) are reviewed.All the treatment studies on fluoxetine, sertraline, paroxetine and citalopram have reported… 
Effects of antidepressants on quality of life in women with premenstrual dysphoric disorder
  • E. Freeman
  • Psychology, Medicine
  • 2012
Although the data show that PMDD is effectively treated with serotonergic antidepressants and that functional impairment that accompanies the disorder is also improved with treatment, the social and economic burden of PMDD continues to be widely unrecognised.
The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta‐analysis
Premenstrual disorder and the adolescent: clinical case report, literature review, and diagnostic and therapeutic challenges
The case of a 16-year-old female diagnosed with premenstrual dysphoric disorder is presented and the diagnosis from an adolescent medicine approach is reviewed, discussing why diagnosis and treatment must be distinct for this age group and different from the adult approach.


Serotonin reuptake inhibitors for the treatment of premenstrual dysphoria.
  • E. Eriksson
  • Psychology, Medicine
    International clinical psychopharmacology
  • 1999
The observation that the symptoms of PMD may be effectively reduced by SSRIs is of considerable clinical importance since previously no effective treatment for this common condition - apart from those disrupting ovarian cyclicity - has been available.
Differential response to antidepressants in women with premenstrual syndrome/premenstrual dysphoric disorder: a randomized controlled trial.
The comparison of 2 classes of antidepressants strongly favored the serotonergic drug, which effectively reduced symptoms and improved functioning and was well tolerated by women with severe premenstrual syndrome.
Efficacy of selective serotonin-reuptake inhibitors in premenstrual syndrome: a systematic review
Sertraline versus desipramine in the treatment of premenstrual syndrome: an open-label trial.
Sertraline and possibly desipramine appear to be effective treatments for PMS, and sertralines was better tolerated, resulting in greater patient acceptance, and a placebo-controlled trial is clearly needed to support or refute these preliminary findings.
A placebo-controlled clinical trial of l-tryptophan in premenstrual dysphoria
Comparison of fluoxetine, bupropion, and placebo in the treatment of premenstrual dysphoric disorder.
Fluoxetine was significantly superior to bupropion and placebo as an effective treatment for PMDD, and patient satisfaction was far greater with fluoxettine.